TP53 and incontinentia pigmenti: The associated malignancy is predominantly squamous cell carcinoma (SSC), which may arise within the papilloma or is merely associated with a histologically bland IP.2 This group of patients is characterized by older age and male preponderance compared with those without associated malignancy.2,3 An etiological role for human papillomavirus (HPV) and the mutation of the p53 tumor suppressor gene in malignant transformation of IP has been suggested.5–7