Studies have demonstrated the signal transducers and activators of transcription 3 (STAT3) signaling pathway plays a key role in the carcinogenesis by promotion of proliferation, differentiation and cell cycle progression, as well as the inhibition of apoptosis.5,6 The constitutive activation of STAT3 is implicated in a variety of cancer cell lines7–11, which suggests stat3 may be an important molecular target for the anti-tumor therapy. Here, STAT3 is linked to neoplasm.