EGFR is strongly expressed in the keratinocytes, cells of eccrine and sebacceous glands and in the epithelium of hair follicles, and is important for normal skin development and function.4 Blocking cutaneous EGFR signalling with EGFR inhibitors leads to a spectrum of skin reactions which occur in ≥80% of patients, the most common being acneiform rash which occurs most frequently on the head and neck regions and on the trunk. The gene discussed is EGFR; the disease is acneiform dermatitis.