Contrast induced nephropathy (CIN) causes renal failure, increased morbidity, prolonged hospital stay, higher hospitalization costs, and increased mortality.10 Although its pathogenesis remains unclear, CIN is probably due to a combination of decreased renal medullary perfusion (possibly because of alterations in renin-angiotensin system, nitric oxide synthesis, adenosine metabolism, prostacyclin production, and endothelin synthesis)11–13, resulting in critical medullary ischemia and direct tubular toxicity.14 Patients with diabetic nephropathy are at especially great risk from CIN. This evidence concerns the gene REN and cervical squamous intraepithelial neoplasia.