MGMT and glioblastoma: Analysing a different promoter methylation status of key regulator genes implicated in apoptosis and inflammation hypermethylation of TMS1/ASC was significantly more frequent in long-term surviving GBM patients and DAPK promoter hypermethylation was only found in the long-term subset compared to unselected GBM patients.4 Martinez et al.18 found a significantly higher methylation rate of MGMT in long-term GBM patients compared to unselected GBM patients.