Lysosomal proteases cathepsin B and L have been associated with tumour invasiveness.20–22 They were considered as factors contributing to invasiveness of meningiomas.26–28 Higher expressions of cathepsin B, metalloprotease-2 and metalloprotease-9 were also detected in meningiomas, histologically described as invasive.18,32. The gene discussed is CTSB; the disease is neoplasm.