Although the effects of VEGF receptors (VEGFR) signaling were initially thought to be specific for the vasculature, VEGF can also play a role in many other processes.34 VEGFR1 expression by colon cancer cells contributes to colon cancer cell motility and invasiveness but has little direct effect on proliferation of these cells. The gene discussed is FLT1; the disease is malignant colon neoplasm.