In particular, the high myopia with posterior staphyloma group had significantly lower VEGF/PEDF ratios than the high myopia with no complications group and high myopia with chorioretinal atrophy group (p=0.050 and 0.036, respectively; Mann–Whitney test) although axial lengths and refractive errors between high myopia groups are a little different (Table 1). This evidence concerns the gene SERPINF1 and Chorioretinal atrophy.