OPTN and open-angle glaucoma: To date, several causative genes for POAG from these 14 POAG-associated loci have been identified, including myocilin (MYOC) [10,11], optineurin (OPTN) [12], WD repeat domain 36 (WDR36) [13], cytochrome P450 1B1 (CYP1B1) [14], and TANK-binding kinase 1 (TBK1) [15,16] (Human Genome Organization).