CXCL8 and infection: During an infectious insult in the liver, resident macrophages and dendritic cells detect the presence of invading pathogens (via PRRs/PAMPs mechanisms) and will release chemokines CXCL8 (IL-8), CXCL1, 2, 3, CCL2, 3, 4 to attract neutrophils and monocytes at the site of infection (Figure 1) [44, 46, 47].