Expression of the epidermal growth factor receptor gene, HER2, which is implicated in malignant transformation, was also used to characterize the cell lines, as overexpression is reported on average in 20-30% of ovarian tumors and as high as 75% by a variety of techniques including ELISA, immunohistochemistry and RT-PCR [38-41]. Here, EGFR is linked to ovarian neoplasm.