For PIK3CA mutations, screening revealed the occurrence of six mutations (p.E542K, p.E545A, p.E545G, and p.E545K in exon 9; p.M1043I and p.H1047R in exon 20), which have been widely reported in mutation databases (HGMD and COSMIC; see above) as commonly associated with CRC, with a recognized functional role of the corresponding mutated proteins. Here, PIK3CA is linked to colorectal carcinoma.