PIK3CA and colorectal carcinoma: Controversial data have been instead published about the PIK3CA mutation rates, ranging from 7% [26] to 30% [27] of CRC cases presenting a mutated PIK3CA. In the present study, all detected PIK3CA variants have been previously demonstrated to be oncogenic in CRC cellular models [28] and commonly associated with colorectal carcinoma (17%; see Table 3); the mutation rate was therefore comparable with that described in majority of previous reports.