Immunoblotting and coimmunoprecipitation studies showed that NS3 protein also interacts with NS5 protein in DEN-2 infected monkey kidney cells and HeLa cells co-infected with a recombinant vaccinia virus [45].Chow and colleagues studied NS3 gene targets of all four dengue serotypes using RT-PCR followed by ELISA. Here, KRAS is linked to dengue disease.