NR1H4 and inflammatory bowel disease: Upon adjustment for age and gender, the uncorrected significance (P<0.05) of genotype frequency association with IBD remained for rs3863377, but was reduced to P>0.05 for rs56163822. There were no significant differences in the allele frequency distribution between the subject groups for NR1H4 variants rs7138843, rs10860603, and rs35724.