NR1H4 and cholelithiasis: Five NR1H4 SNPs were analyzed, all of which have previously been studied in the context of other human disease conditions: rs3863377, rs7138843, rs56163822, rs35724, and rs10860603. The NR1H4 variants rs7138843 and rs56163822 have been previously shown to be inversely associated with cholelithiasis in a Mexican population and may thus play a protective role in gallstone disease, while the variant rs3863377 showed no association with cholelithiasis [51].