AQP1 and ovarian hyperstimulation syndrome: Considering the observed high levels of estrogen, exceeding normal physiological levels, in patients undergoing ovarian hyper stimulation [25,26] and regulation of CFTR and AQP1 expression by ovarian hormones in humans [14], the present findings in OHSS rodent models are of strong clinical relevance, suggesting the coactions of CFTR and AQP1 in the pathogenesis of OHSS.