Considering the observed high levels of estrogen, exceeding normal physiological levels, in patients undergoing ovarian hyper stimulation [25,26] and regulation of CFTR and AQP1 expression by ovarian hormones in humans [14], the present findings in OHSS rodent models are of strong clinical relevance, suggesting the coactions of CFTR and AQP1 in the pathogenesis of OHSS. Here, CFTR is linked to ovarian hyperstimulation syndrome.