BAX and neoplasm: As seen in a previous study on the apoptotic process, it is reasonable to assume that the immunological anti-tumoral activity and cell death [40] process is concentrated mainly in the cirrhotic tissues surrounding a tumor, where the presence of large numbers of lymphocytes, monocytes/macrophages and Kupffer cells releasing large quantities of ROS and cytokines [41] may prompt the upregulation of apoptotic factors such as Bax, Bad and Bcl-2.