PRNP and neuroblastoma: Effects of HuPrP106-126 on cells include aggregation of PrPC in neuroblastoma cells[7], copper uptake inhibition in cerebellar neurons[8], p38 MAPK activation in correlation with cell death in SH-SY5Y cells[9] and an increase in intracellular Ca2+ coupled with membrane viscosity in leucocytes[10].