Although several studies demonstrated NKX2.1 to be a lineage-specific oncogene and its expression was found to be crucial for the survival of a subset of adenocarcinomas [161, 167], a recent mouse model links NKX2.1 downregulation to a loss in differentiation, enhanced tumor-seeding ability, and increased metastatic proclivity [172]. Here, NKX2-1 is linked to adenocarcinoma.