EPHX1 and colorectal carcinoma: Figure S3A shows results from the cumulative meta-analysis of the association of the EPHX1 Tyr113His with overall CRC in chronologic order. Inclinations toward null significant associations were evident with each accumulation of more data over time. Figure S3B shows results from the cumulative meta-analysis of the association of the EPHX1 His139Arg with overall CRC in chronologic order.