PIK3R2 and thyroid gland carcinoma: We have found a consensus p85 binding site (YxxM) in the N-terminus of XB130 that can bind to either the N-or the C-terminal SH2 domain of p85α determined by GST-fusion protein pull-down assays, and that XB130 is co-immunoprecipitated with p85α in human thyroid carcinoma TPC-1 cells.