To explore the role of XB130 in cancer cell cycle progression we conducted knockdown experiments using XB130 siRNA in human thyroid follicular carcinoma WRO cells (with RET-PTC rearrangement) and in human lung adenocarcinoma A549 cells (a cell line commonly used in lung cancer studies [15]). Here, AFAP1L2 is linked to thyroid gland follicular carcinoma.