PCOS-like traits are most prominent in female monkeys exposed to fetal male-typical T levels during early-to-mid gestation and include ovarian and adrenal androgen excess, intermittent or absent menstrual cycles, polycystic ovaries, increased adiposity, hyperlipidemia, insulin resistance and impaired insulin secretion, as well as increased incidence of type 2 diabetes mellitus [34]–[40]. Here, INS is linked to type 2 diabetes mellitus.