CNR2 and metabolic dysfunction-associated steatohepatitis: When we stratified the sub-group of 55 children I148M PNPLA3 heterozygous for the Q63R CB2 variant, we found that the presence of NASH among these patients was significantly associated to the presence of the R63 CB2 allele (p = 0.001; Fig. 2B) and that the odds ratio-associated p value was 0.0001.