Performing a multivariate analysis incorporating both I148M PNPLA3 and Q63R CB2 variants, as well as age, sex, waist circumference and HOMA-IR, the association with inflammation and steatosis, driven by the PNPLA3 genotype, was significant (p<10−4), whereas the association with fibrosis was not (p = 0.08) (Table S2). This evidence concerns the gene CNR2 and steatosis.