AFAP1L2 and gastric cancer: The clinical prospective of this study includes (1) XB130 may act as GC prognostic biomarker for its low expression implicating for unfavorable outcomes; (2) Since XB130 low expressed GC are responsive to cisplatin and irinotecan superior to 5-fluorouracil in our chemotherapeutic sensitivity study, assessment of XB130 expression may help guide clinical medication in GC.