In the present study, DBT not only inhibited the expression of growth factors including VEGF, TGF-β1, and Ang1, but also downregulated their receptors expression and ERK phosphorylation which is common cytoplasmic mediator, indicating that the inhibition of VEGF, TGF-β1 and Ang1 and their signaling is another important mechanism for DBT action on HIF-1α, and against angiogenesis and liver fibrosis. The gene discussed is VEGFA; the disease is Hepatic fibrosis.