On the other hand, in advanced stages, TAM polarize to a type-2-macrophage- (M2-) related cell that releases cytokines such as TGF-β1 and IL-10, which induce Th2 differentiation and recruitment, favoring Tregs development and thus promoting tumor development through inhibition of anticancer immune responses [112]. This evidence concerns the gene TGFB1 and neoplasm.