HL was the first hematopoietic tumor to be characterized as having clearly aberrant nuclear factor-κB (NF-κB) activity that appears closely linked to the cellular interactions within the bone marrow microenvironment: direct contact of tumoral cells with the EMC, bone marrow stromal cells (BMSCs), osteoblasts, or other cellular compartments in the BM. Here, NFKB1 is linked to Hodgkins lymphoma.