Regardless of the classic clinical and pathological features, a high proportion of infiltrating CD8+ and CD57+ cells as well as a low number of infiltrating CTL (evaluated by the presence of Granzyme B and TIA-1) appear to be associated with a favorable outcome for HL patients (without B symptoms and lower clinical stages) and better response to treatment [10, 24, 147]. This evidence concerns the gene GZMB and Hodgkins lymphoma.