IGHE and chronic rhinosinusitis with nasal polyps: The overproduction of IL-5 might intensify eosinophilic inflammation in aspirin-sensitive patients [72] and is correlated to increased levels of IgE and Staphylococcus aureus enterotoxins(SAE) present in nasal polyp tissue but is not specific for patients suffering from CRSwNP and aspirin sensitivity [73].