VEGFA and osteosarcoma: In fact, strontium-doped-calcium-polyphosphate-(SCPP) based bioceramic scaffolds combined with the rat osteosarcoma cell line ROS17/2,8 promoted cell proliferation and induced mRNA expression and release of two angiogenic factors, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) [62–64].