In order to evaluate the functional consequences of IGF-IR inhibition in adrenal carcinomas, Barlaskar et al. analyzed a large series of benign and malignant human adrenal tumors and a panel of ACC cell lines using a tyrosine kinase inhibitor, NVP-AEW541, and a fully human monoclonal antibody anti-IGF-IR, IMC-A12, both specifically targeting IGF-IR. This evidence concerns the gene IGF1R and adrenal cortex carcinoma.