Moreover, through the same pathways, IGFs regulate cell invasion and tumor-dependent angiogenesis modulating the expression of molecular mediators of extracellular matrix remodeling and degradation including type IV collagenases, matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), and the membrane type 1 MMP (MMP-14) [91, 92]. This evidence concerns the gene MMP9 and neoplasm.