Key predisposing factors to DM2 in such women include (1) obesity before and after pregnancy, (2) number of pregnancies, (3) age, (4) need for insulin therapy due to GDM, (5) obstetric failure, and (6) a positive family history of DM2 [2, 6–8]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.