This cytokine is produced by a wide variety of cells, and it is involved in both RA and atherosclerosis pathogenesis [63, 64]: circulating IL-6 concentration has been associated with endothelial activation and treatment with traditional disease modifying antirheumatic drugs, resulting in a suppression of IL-6, has been associated to a reduced endothelial activation in patients with RA [65, 66]. This evidence concerns the gene IL6 and rheumatoid arthritis.