Also by IHC and TMA, Mcm-2 has been proved to be a proliferative sensitive marker for SGTs and PLUNC proteins have been suggested to be useful diagnostic tools for mucoepidermoid carcinoma, whereas geminin has been strongly associated with reduced overall and relapse-free survival rates in patients affected by salivary gland carcinomas (1,19,20). This evidence concerns the gene BPIFA1 and salivary gland carcinoma.