Among the bone remodeling biochemical markers, we observe very high osteocalcin and aminoterminal propeptid (P1NP) average values in the group of patients with neoplasia, compared to the group of patients with osteoporosis, which indicates high osteoblastic activity in patients with neoplasia (particularly breast and prostate) possibly related to the bone metastasis. Here, BGLAP is linked to neoplasm.