NSD1 and Intellectual disability: However, in contrast to Sotos individuals with NSD1 mutations, Sotos patients with 5q35 microdeletions tend to show less pronounced overgrowth but more profound intellectual disability (Kurotaki et al. 2003; Nagai et al. 2003; Saugier-Veber et al. 2007; Tatton-Brown et al. 2005a), and several studies have reported an increased frequency of cardiovascular and urinary/renal abnormalities in 5q35 microdeletion Sotos patients (Kurotaki et al. 2003; Nagai et al. 2003; Saugier-Veber et al. 2007).