It has recently been shown in epidemiological studies (Bergman et al. 2010; Liu et al. 2011; Haubenberger et al. 2011) that polymorphisms in the Pitx3 gene are associated with sporadic and early-onset forms of Parkinson’s disease (PD), which account for approximately 90 % of PD cases. Here, PITX3 is linked to Parkinson disease.