Analysis of canonical pathways also revealed the Integrin pathway as most significant (including ITGA2: fold 5.0, ITGA3: fold 3.1, ITGA6: fold 5.3, ITGB1: fold 2.0, ITGB4: fold 5.8, ITGB5: fold 5.0 and ITGB6: fold 5.4; all p < 0.001), on top of the Ephrin receptor signalling (including EPHA2: fold 7.3, xEPHB4: fold 2.0, EFNA5: fold 3.9 and EFNB2: fold 3.0; all p < 0.001), the Wnt/β-catenin pathway and pancreatic adenocarcinoma signalling (Table 2). Here, ITGB4 is linked to pancreatic adenocarcinoma.