PMEL and neoplasm: Among CM Ag outstands melanocyte differentiation Ag (MD-Ag) such as MART-1 [21, 22], gp100 [23], tyrosinase [24], tyrosinase-related protein-1 (TRP1) [25], TRP2 [26], and MELOE-1 [27]; cancer-testis Ag from the MAGE super-family [28] and NY-ESO-1 [29]; and tumor-mutated Ag such as BRAF [30].