Autoantibodies to β2AR in CRPS patients, for instance, could bind to β2AR receptors located on microglia (Mantyh et al. 1995; Wang et al. 2010), leading to autoimmune attack on these neuroimmune cells, as well as specific types of neurons and astrocytes, which also express β2AR. The gene discussed is ADRB2; the disease is complex regional pain syndrome.