In PCa, recurrent gene fusions occurring between the transmembrane protease, serine 2 (TMPRSS2) gene, an androgen-regulated prostate-specific serine protease and members of the erythroblast transformation-specific (ETS) family of transcription factors [ETS variant gene (ETV)-1, ETV-4, ETV-5 and most commonly, ETS-related gene ERG] resulting in the increased expression of the latter rearranged ETS members in response to androgens, are frequently found (2–4). The gene discussed is ETV4; the disease is posterior cortical atrophy.