ERG and posterior cortical atrophy: As the most prominent gene rearrangement in PCa leads to the overexpression of ERG (20–23), combined with functional studies showing that ERG knockdown induces morphological changes, inhibits cell growth in both culture and mice, and that ERG overexpression leads to an increase in cell invasion (24), the aim of the present study was to investigate whether ERG is part of a complex integrated transcriptional network that involves other ETS factors which are highly likely to cooperate or influence the activity of ERG in PCa.