Given the fact that these findings do not mirror previously reported findings in transformed NIH-3T3 cells[7], we analysed the effect of reovirus infection and 2-AP treatment on L929 cells and the 4 relatively reovirus-resistant head and neck cancer cell lines using immunocytochemistry to measure p-PKR staining and western analysis to define downstream phosphorylation of EIF2α (which acts to inhibit viral protein translation). The gene discussed is EIF2AK2; the disease is head and neck cancer.