F10 and Stroke: Similarly, in the study of Apixaban vs Warfarin in Patients with Atrial Fibrillation (ARISTOTLE), apixaban, a factor Xa inhibitor was superior to warfarin in preventing stroke or systemic embolism, caused less bleeding, and resulted in lower mortality [19], while rivaroxaban in the Rivaroxaban Once-daily oral direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation (ROCKET-AF) study was shown to be non-inferior to warfarin in patients at the highest risk of stroke [20].