MPO and chronic pancreatitis: MPO and Mac-3 positive cells were further semi-quantified by counting the number of positive cells per high power field (40× objective lens), as shown in Figure 3C, compared with caerulein induced chronic pancreatitis mice, a significant reduction of MPO and Mac-3 positive cells were observed in sulindac treated chronic pancreatitis mice (MPO labeled neutrophiles: 28.6 ± 18.8 versus 86.9 ± 28.5/HPF; and Mac-3-labled macrophages: 25.3 ± 16.7 versus 72.1 ± 21.2, The average inflammatory cell infiltration score was 1.46 ± 0.58 versus 2.66 ± 0.75, respectively.