Similar as the results of qPCR assay, as shown in Figure 4H, the protein expression of PDGF-β, TGF-β, SHH and GLi1 were all up regulated in caerulein induced chronic pancreatitis mice, significantly decreased expression of these proteins were observed in chronic pancreatitis mice with sulindac treatment (p < 0.05). Here, SHH is linked to chronic pancreatitis.