Our results showed that inhibition of chronic pancreatitis by sulindac was through a significant reduction of myeloperoxidase-labeled neutrophils and Mac-3-positive macrophages infiltration in the pancreas which is also paralleled with significant decrease of pancreatic injury as measured by amylase and cytokeratin-19 and Masson trichrome staining labeled pancreatic fibrosis. Here, MPO is linked to chronic pancreatitis.