In statistical analysis the median of LSD1 expression level (IRS) was significantly increased during tumour progression from pre-invasive to invasive ductal breast carcinoma (low grade DCIS = 8, intermediate grade DCIS = 10, high grade DCIS = 12, invasive ductal breast carcinoma = 12) (p <0.05, Kruskall-Wallis-H-test) (Table 2, Figure2). Here, KDM1A is linked to ductal breast carcinoma in situ.