The hepatic flare was asymptomatic in 8 and symptomatic in 2 patients (Table 1): a 68-year-old male with DLBCL who developed HCV reactivation and a hepatic flare two weeks after the third cycle of R-CHOP and died of acute liver failure and a 65-year-old female with DLBCL who developed severe ascitis after four cycles of R-CHOP and died 1 week later for the uncontrolled progression of the underlying oncohaematological disease. The gene discussed is DDIT3; the disease is acute liver failure.