ERBB2 and neoplasm: In the multivariate analysis, several factors were associated with poor OS, including tumor stage 3/4 (HR 2.7, 95% CI 1.7–4.4, P < 0.001), hormone-receptor-negative tumors (HR 0.2, 95% CI 0.1–0.6, P = 0.003), HER2 negative disease (HR 0.3, 95% CI 0.1–0.8, P = 0.015), multiple metastatic sites (HR 1.6, 95% CI 1.0–2.4, P = 0.047), presence of visceral metastases (HR 1.6, 95% CI 1.0–2.5, P = 0.042), and mean glucose >130 mg/dL (HR 2.8, 95% CI 1.1–7.3, P = 0.034).