Looking at median levels of gene expression in tumor compared to adjacent nontumor tissues, the DNMT3B mRNA expression was downregulated (median = 0.4, Q1–Q3 = 0.22–1.05, P = 0.03), while PPARγ and DNMT1 mRNA levels were not significantly altered (PPARγ: median = 0.98, Q1–Q3 = 0.41–1.8, P = 0.54; DNMT1: median = 0.76; Q1–Q3 = 0.61–1.29, P = 0.4). The gene discussed is DNMT3B; the disease is neoplasm.