DNMT3B and pachyonychia congenita: Furthermore, DNMT3B expression levels showed a borderline association with perineural invasion in PC patients: DNMT3B levels were higher in patients with evidence of perineural invasion (median = 0.98, Q1–Q3 = 0.67–1.07) than in those without tumor invasion into neural structures (median = 0.26, Q1–Q3 = 0.18–0.62), P = 0.06 (Figure 2).