Our study demonstrated that PPARγ positively correlates with DNMT1, but not with DNMT3B, and that higher DNMT3B mRNA levels in presence of noninvasive tumor predict longer survival in pancreatic cancer patients whereas in presence of invasive tumour higher DNMT3B mRNA levels were associated with a poor prognosis. This evidence concerns the gene DNMT3B and pancreatic neoplasm.