The frequency of the VEGFR-2 genotype rs2071559 AA was 18.33% in patients with AMD, while in controls it was 34.62% with a statistically significant difference equal to a value of P = 0.0095 (Pcorr = 0.038; chi-square test, Table 3) and a calculated OR of 0.42 (95% CI 0.22 to 0.82). This evidence concerns the gene KDR and age-related macular degeneration.