TP53 and neoplasm: A number of small molecules that promote p73-dependent apoptosis by increasing p73 expression or by extricating p73 from inhibitory complexes with mutant p53 have been identified.16,17 Alternatively, p73 activation has been promoted by blocking its interaction with inhibitors, such as iASPP and MDM2.18,19 The tumor suppressor function of p73 is lost upon its phosphorylation by the Aurora A kinase.20