One study reported a correlation between the CSF/serum index of antibodies directed against NFL and brain atrophy, but this study analysed only patients with relapsing remitting or progressive forms of MS, and no relation with NF proteins was observed.21 None of the CSF markers of axonal damage analysed in our study correlated with T2 lesion volume at baseline or its change over time. The gene discussed is NFASC; the disease is Brain atrophy.