Whereas silencing of eIF4E mRNA expression had no effect on COX Vb mRNA expression (Figure2A), COX Vb protein expression in the hT/LT-immortalized, H-RasV12-transformed cells and K-RasS12 positive A549 lung adenocarcinoma cells was reduced by transfection with the eIF4E siRNA species (Figure2B, C). The gene discussed is COX5B; the disease is lung adenocarcinoma.