ESCC patients with elevated SAA levels had significantly shorter overall survival rate compared to patients with non-elevated SAA levels in the clinical stage I-II subgroup (n = 64; log-rank P < 0.0001; Figure 3b), the clinical stage III-IV subgroup (n = 101; log-rank P < 0.0001; Figure 3c), the T1-T2 subgroup (n = 34; log rank P = 0.016; Figure 3d), the T3-T4 subgroup (n = 131; log rank, P < 0.0001; Figure 3e), the N0 subgroup (n = 72; log rank, P < 0.0001; Figure 3f) and the N1 subgroup (n = 93; log-rank, P < 0.0001; Figure 3g). Here, SAA1 is linked to esophageal squamous cell carcinoma.